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Freeze Dried Bifidobacterium Lactis

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seat:
Beijing
Validity to:
Long-term effective
Last update:
2022-08-23 14:29
Browse the number:
505

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Company Profile

Probioway Co., Ltd.

By certification [File Integrity]

Contact：probioway3616(Mr.)

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Area：Beijing

Address：Beijing

Website：http://www.probioway.com/ http://probioway3616.china-jinquan.com/

PRODUCT DETAILS

PRODUCT DESCRIPTION

Bifidobacterium lactis HH-BA68 powder contains the Bifidobacterium lactis HH-BA68 and a special protective agent. This strain was isolated from healthy infant intestine, it can survive in the acidic gastric environment and reach the small intestine and colonize the host. In where, it acts in sevearl ways to enhance health.

SPECIFICAITON

Strain name	Bifidobacterium lactis	Strain number	HH-BA68
Potency	500bn cfu/g	Gene Identification	Yes
Deposit	CCTCC	Certification	ISO9001/ISO22000/FSSC22000/HACCP/HALAL/KOSHER/FDA
Packing	500g,1kg or 5kg per foil bag	Storage	-18℃ for long time, 2-8℃ for short time

TECHNICAL INDICATORS

Items		Specification
1) Live Bifidobacterium lactis potency		≥ 5.0×1011 CFU/g
2) Water content		≤8.0%
4) Coliforms		≤10CFU/g
5) Moulds, Yeasts		≤10CFU/g
6) Pathogenic bacteria		Negative
7) Heavy metals	Lead (Pb)	≤1ppm
	Arsenic (As)	≤0.5ppm

RELEVANT RESEARCH

Strain Name

Identification

Deposit No.

Antibiotic Susceptibility

Acid and Bile Salt resistance

Stability

Quality System

B.lactis HH-BA68

16S rRNA

Done

SC/ISO9001/ISO22000/FSSC22000/HACCP/

HALAL/KOSHER/FDA

ACID TOLERANCE

Acid resistance of Bifidobacterium lactis HH-BA68 powder was carried out at either pH=2.0 and pH=3.0 for up to 4 hours. The microbial enumeration of Bifidobacterium lactis HH-BA68 should be performed no more frequently than at the initial(as control), 1 hour, 2 hour, and 4 hour time points. The Fig 1 illustrates that Bifidobacterium lactis HH-BA68 can survive at low pH conditions, which means this strain has good acid resistance.

Fig 1. Acid resistance of B.lactis HH-BA68

BILE SALT TOLERANCE

Bile salt resistance of Bifidobacterium lactis HH-BA68 powder was carried out at either 0.2% and 0.3% bile salt for up to 4 hours. The microbial enumeration of Bifidobacterium lactis HH-BA68 should be performed no more frequently than at the initial(as control), 1 hour, 2 hour, and 4 hour time points. The Fig 2 illustrates that Bifidobacterium lactis HH-BA68 can survive at high concentration of bile salt, which means this strain has good bile salt resistance.

Fig 2. Bile salt resistance of B.lactis HH-BA68

STORAGE STABILITY

Bifidobacterium lactis HH-BA68 powder were sealed in aluminum foil bag, maintained at -18℃ for 24 months for long-term stability test. The microbial enumeration of Bifidobacterium lactis HH-BA68 should be performed no more frequently than at the initial, 1, 2, 3, 6, 9, 12, 15, 18, 21, 24 month time points. According to Fig 3, the potency of Bifidobacterium lactis HH-BA68 powder was 4.40×10¹¹CFU/g. After a storage period of 24 months, the potency of the powder was 3.60×10¹¹CFU/g. It means that this strain can remain stable for long time if stored at low temperature.

Fig 3. Storage stability of B.lactis HH-BA68

HEALTH BENEFITS

1.Inhibit pathogen colonization

The aim of this study was evaluation of antagonistic effect of B.lactis HH-BA68 against colonization by pathogens. The results showed(Table 1) that B.lactis HH-BA68 is critical in providing resistance against colonization by four pathogenic microorganisms.

	S.aureus	C.difficile	S.typhimurium	L.monocytogenes
Colonization inhibition rate（%）	48.0±3.6	27.8±6.4	5.2±3.8	25.7±8.0
Colonization replacement rate（%）	25.7±7.5	56.7±7.4	7.4±2.8	43.8±7.3

Table 1. Pothogen colonization inhibitory ability of B.lactis HH-BA68

2.Inhibit pathogen growth

The aim of this study was evaluation of antagonistic effect of B.lactis HH-BA68 against four pathogens. Antimicrobial effects of isolates were evaluated by disc diffusion test on plates with different pathogens. Growth inhibition zones of pathogens and B.lactis HH-BA68 inhibitory ability were assessed after incubation of all agar media at 37℃ for 24h. The results showed (Table 2) that B.lactis HH-BA68 had relatively strong activity against tested pathogens (with inhibition zone diameter> 15mm).